Relative roles of metabolism and renal excretory mechanisms in xenobiotic elimination by fish.

Relative roles of metabolism and renal excretory mechanisms in xenobiotic elimination by fish.

Renal clearance techniques were used to examine the relative contributions of metabolism and renal tubular transport in determining the rates of excretion of benzo(a)pyrene (BaP) and several of its phase I metabolites by southern flounder, Paralichthys lethostigma. Each compound (3H-labeled) was injected at a dose of 2.5 mumole/kg, producing plasma concentrations of 1 to 5 microM. Despite exten...

Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes

     It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...

pragmatic transfer in compliment responses and chastisements by iranian learners of english

فرهنگ های گوناگون دریافت ها و تعبیر های مختلفی از تناسب و ادب دارند. بنابراین، ارتباط میان فرهنگی خطرات ذاتی خطای ارتباطی را نشان می دهد. این پژوهش به منظور تعیین وقوع انتقال منظورشناختی زبان در زبان بینابینی زبان آموزان ایرانی، اختلاف منظورشناختی زبان را بین فارسی و انگلیسی در کنش های کلامی پاسخ تحسین و انتقاد بررسی می کند.داده ها از میان 33 آمریکایی انگلیسی زبان، 85 زبان آموز ایرانی در سطوح م...

Xenobiotic metabolism by cultured primary porcine hepatocytes.

Considering the large yield of viable cells comparable to human liver, primary porcine hepatocytes offer a valuable resource for constructing a bioartificial liver device. In this study, the ability of cultured primary porcine hepatocytes to detoxify xenobiotics has been examined using various known substrates of cytochrome P450 isoenzymes and UDP-glucuronosyltransferases. Present investigation...

Development and characterisation of a three-dimensional in vitro hepatic fish model to investigate xenobiotic metabolism